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Developmental genomic approaches in model organisms.

Valerie Reinke1, Kevin P White

  • 1Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA. valerie.reinke@yale.edu

Annual Review of Genomics and Human Genetics
|July 27, 2002
PubMed
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Functional genomics, using tools like DNA microarrays, helps understand how genomes direct organism development. This review covers recent advances in mapping genome-wide developmental processes.

Area of Science:

  • Developmental Biology
  • Genomics
  • Molecular Biology

Background:

  • Understanding complex organism development requires linking genomic information to biological outcomes.
  • Functional genomics technologies offer powerful tools to study these links.
  • Recent research applies these tools to developmental processes.

Purpose of the Study:

  • To review the application of functional genomics in developmental studies.
  • To discuss genomics approaches in animal models for human disease.
  • To outline methods for mapping genome-wide developmental processes.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of functional genomics approaches (e.g., DNA microarrays).
  • Discussion of methods for genome-wide mapping in development.

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Main Results:

  • Functional genomics is increasingly used to study development.
  • Genomics approaches in model systems are advancing human disease research.
  • Methods for genome-wide developmental mapping are being developed.

Conclusions:

  • Functional genomics is crucial for deciphering developmental processes.
  • Genomics offers insights into human diseases through model systems.
  • Future work will focus on comprehensive genome-wide developmental maps.