Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Poliovirus cell entry: common structural themes in viral cell entry pathways.

James M Hogle1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA. hogle@hogles.med.harvard.edu

Annual Review of Microbiology
|July 27, 2002
PubMed
Summary

Viral entry mechanisms were elucidated through structural and biochemical studies, revealing a pathway involving receptor-mediated conformational changes and genome release. This model offers insights into viral pathogenesis and therapeutic strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanism of enterovirus VP0 maturation cleavage based on the structure of a stabilised assembly intermediate.

PLoS pathogens·2024
Same author

Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.

Cell·2024
Same author

Mechanism of enterovirus VP0 maturation cleavage based on the structure of a stabilised assembly intermediate.

bioRxiv : the preprint server for biology·2024
Same author

A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex.

PLoS pathogens·2023
Same author

Production of antigenically stable enterovirus A71 virus-like particles in <i>Pichia pastoris</i> as a vaccine candidate.

The Journal of general virology·2023
Same author

Production of antigenically stable enterovirus A71 virus-like particles in <i>Pichia pastoris</i> as a vaccine candidate.

bioRxiv : the preprint server for biology·2023

Area of Science:

  • Virology
  • Structural Biology
  • Molecular Biology

Background:

  • Polio- and related viruses utilize specific cell entry pathways.
  • Understanding viral entry is crucial for developing antiviral therapies.

Purpose of the Study:

  • To propose a detailed model for the cell entry pathway of polio- and related viruses.
  • To compare this model with entry mechanisms of enveloped viruses like influenza and HIV.

Main Methods:

  • Structural studies of viral intermediates.
  • Kinetic, biochemical, and genetic analyses.
  • Comparative analysis with other viral systems.

Main Results:

  • A model for viral cell entry involving receptor-induced conformational changes.

Related Experiment Videos

  • Identification of a metastable viral state.
  • Viral RNA genome release into the host cytoplasm.

    • Conclusions:

    • The proposed model provides a comprehensive understanding of picornavirus entry.
    • Viral entry mechanisms share common principles with enveloped viruses.
    • Further research can target identified viral intermediates for therapeutic intervention.