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Triglycerides predict plasma fibronectin in children with type I diabetes mellitus rather than diabetes

Ayşe Binnur Erbağci1, Mehmet Tarakçioğlu, Ahmet Erbağci

  • 1School of Medicine, Department of Biochemistry and Clinical Biochemistry, University of Gaziantep.

Acta Medica (Hradec Kralove)
|July 30, 2002
PubMed

Insights

Plasma fibronectin is not elevated in children with type 1 diabetes. However, high triglycerides, common in diabetes, are linked to higher fibronectin, potentially impacting atherogenesis.

Area of Science:

  • Endocrinology
  • Cardiovascular Research
  • Biochemistry

Background:

  • Fibronectins are adhesive proteins and markers of endothelial activation.
  • Plasma fibronectin levels in diabetes mellitus (DM) correlate with atherosclerotic risk factors.

Purpose of the Study:

  • To investigate plasma fibronectin levels in children with type 1 DM.
  • To examine the relationship between plasma fibronectin and serum lipids, apolipoproteins AI, B100, and Lp(a) in diabetic children.

Main Methods:

  • Nephelometric methods were used to determine fibronectin and apolipoprotein concentrations.
  • Study included 35 children with type 1 DM and 30 age/gender-matched non-diabetic controls.

Main Results:

  • Plasma fibronectin levels did not differ significantly between diabetic children and controls.
  • HbA1c and triglycerides were significant predictors of plasma fibronectin in diabetic children.
  • Diabetic children with triglycerides < 1.13 mmol/L showed elevated plasma fibronectin compared to controls with similar triglyceride levels.

Conclusions:

  • Plasma fibronectin is not elevated in children with type 1 DM.
  • High plasma triglycerides, regardless of diabetic status, are associated with increased plasma fibronectin, suggesting a role in atherogenesis.
  • Plasma cholesterol, apolipoproteins AI, B100, and Lp(a) were not significant determinants of plasma fibronectin in this cohort.

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