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Clostridium difficile-associated diarrhea and chronic renal insufficiency
Khurshid Yousuf1, Mohammad G Saklayen, Ronald J Markert
1Veterans Affairs Medical Center and the Deaprtment of Medicine, Wright State University, Dayton Ohio, USA.
Southern Medical Journal
|July 30, 2002
Summary
Chronic renal insufficiency does not cause Clostridium difficile-associated diarrhea (CDAD), but it significantly increases mortality and recurrence rates in patients diagnosed with CDAD.
Area of Science:
- Infectious Diseases
- Nephrology
- Gastroenterology
Background:
- Clostridium difficile-associated diarrhea (CDAD) is a significant cause of hospital-acquired illness.
- Previous reports suggest a potential link between renal failure and CDAD.
- The role of chronic renal insufficiency as a risk factor for CDAD requires further investigation.
Purpose of the Study:
- To determine if chronic renal insufficiency is a risk factor for developing CDAD.
- To evaluate the impact of chronic renal insufficiency on CDAD-related mortality and morbidity.
Main Methods:
- A retrospective chart review was conducted.
- 385 patients with diarrhea were analyzed.
- Data collected included CDAD status, chronic renal insufficiency, mortality, and CDAD recurrence.
Main Results:
- Out of 385 patients, 77 were diagnosed with C. difficile infection.
- No significant difference in chronic renal insufficiency or comorbidities was found between patients with and without C. difficile infection.
- Patients with both CDAD and chronic renal insufficiency exhibited significantly higher mortality and CDAD recurrence rates.
Conclusions:
- Chronic renal insufficiency is not identified as a direct risk factor for acquiring CDAD.
- The presence of chronic renal insufficiency exacerbates outcomes in patients with CDAD, leading to increased mortality and recurrence.