Clostridium difficile-associated diarrhea and chronic renal insufficiency
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Published on: December 8, 2014
Khurshid Yousuf1, Mohammad G Saklayen, Ronald J Markert
1Veterans Affairs Medical Center and the Deaprtment of Medicine, Wright State University, Dayton Ohio, USA.
Background:
Clostridium difficile-associated diarrhea (CDAD) is a common cause of mortality and morbidity in hospitalized patients. Some case reports have implicated renal failure as a risk factor for CDAD. The aim of this study was to assess whether chronic renal insufficiency is a risk factor for CDAD and whether it increases mortality and morbidity.
Method:
We reviewed charts of 385 patients with diarrhea for CDAD, chronic renal insufficiency, mortality, and recurrence of CDAD.
Results:
Seventy-seven patients had infection due to C difficile. There was no difference in the chronic renal insufficiency, mortality, and other comorbid conditions between patients who had C difficile infection and those who did not. The patients with CDAD and chronic renal insufficiency had significantly higher mortality and recurrence of CDAD than patients without chronic renal insufficiency.
Conclusions:
Chronic renal insufficiency is not a risk factor for CDAD, but its presence with CDAD increases mortality and recurrence of CDAD.
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