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Related Experiment Videos

Acetaminophen (paracetamol)-induced anaphylactic shock.

Claude Bachmeyer1, Christophe Vermeulen, Redouane Habki

  • 1Département de Médecine Interne, Hôpital Laënnec, Creil, France.

Southern Medical Journal
|July 30, 2002
PubMed
Summary

Anaphylactic shock from acetaminophen (paracetamol) is rare but possible. This case highlights acetaminophen as a potential cause of severe allergic reactions, even with negative initial allergy tests.

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Area of Science:

  • Clinical Immunology
  • Pharmacovigilance
  • Allergy and Immunology

Background:

  • Acetaminophen (paracetamol) is a common over-the-counter analgesic and antipyretic medication.
  • Adverse allergic reactions to acetaminophen are infrequently reported in medical literature.

Observation:

  • A patient experienced anaphylactic shock after taking acetaminophen.
  • Standard allergy testing, including skin prick and intradermal tests, yielded negative results for acetaminophen.

Findings:

  • Oral rechallenge with acetaminophen induced generalized urticaria.
  • Histamine levels in the patient's plasma significantly increased following acetaminophen ingestion.

Implications:

  • This case suggests acetaminophen should be considered a potential trigger for anaphylaxis.

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  • The findings underscore the importance of considering drug-induced anaphylaxis in unexplained severe allergic reactions.
  • Further investigation into the mechanisms of acetaminophen-induced hypersensitivity is warranted.