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Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
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The increased histamine release in ischaemic heart disease patients undergoing coronaroangiography is not mediated by

Rosa-Maria Rodriguez1, J-L Guéant, I Aimone-Gastin

  • 1Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition, Equipe INSERM 0014, Faculté de Médecine, BP 184, F-54505 Vandoeuvre-lès-Nancy Cedex, France.

Allergy
|July 30, 2002
PubMed

Insights

Histamine release during coronary angiography is elevated in patients with coronary artery disease. This heightened release is not attributed to IgE or complement activation, suggesting other factors are involved.

Area of Science:

  • Cardiovascular Medicine
  • Allergy and Immunology
  • Radiology

Background:

  • Iodinated contrast media (ICM) can trigger histamine release.
  • Patients with coronary artery disease (CAD) exhibit higher histamine release during coronary angiography compared to non-coronary patients.

Purpose of the Study:

  • To investigate the mechanisms behind elevated histamine release in CAD patients during coronary angiography.
  • To determine if IgE or complement activation mediates histamine release.

Main Methods:

  • Eighty-eight patients undergoing coronary angiography were divided into CAD and non-coronary groups.
  • Plasma histamine, IgE, and complement fractions (C3c, C4) were analyzed.
  • Radioimmunoassays (RIA) were used to detect anti-ICM IgE.

Main Results:

  • No significant differences in total IgE or complement fractions were observed among groups.
  • Elevated histamine levels were found in 7 patients, predominantly those with CAD.
  • Anti-ICM IgE levels were higher in control groups (normal histamine) than in the high-histamine group.

Conclusions:

  • Histamine release in ischemic heart disease patients during coronary angiography is not mediated by IgE or complement.
  • Further research is required to identify the specific factors responsible for histamine release.
Abstract

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