14CH3-N-pethidine biotransformation in the rat and rabbit isolated perfused liver during the pathological process

The demonstration of decreased hydrolysis and demethylation of pethidine in the liver subcellular fractions in the course of acute radiation sickness was not verified under the conditions of perfusion of the isolated liver. An attempt was made to interpret the discrepancy in the findings by a change in the intensity of uptake of pethidine and its metabolites in liver tissue after irradiation.