[Bile and stress ulcer in the rat (author's transl)]

The influence of bile on the ulcer formation under "restraint stress" condition was studied in rats with direct choledocho-gastrostomia resp. bile duct ligation. After 9 hrs. of immobilisation in plaster cuffs the animals with unrestricted bile flow via the choledochosstress gastrostomia showed as many ulcers as the sham-operated controls. There was no difference in the ulcer localisation, the region of the bile duct anastomosis was without any ulcer. After bile duct ligation the ulcer frequency was reduced to the half. These results are explained by a massive bile reflux under stress condition, of which the pathogenetic role in stress ulcer formation is discussed.