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Inv(4)(p14q27) in a case with de novo acute nonlymphocytic leukemia
Silvia Benasayag1, Eugenia Arias, Edgardo Baialardo
1Centro de Estudios Genéticos (CEG), Instituto de Investigaciones Hematológicas Mariano R. Castex, Academia Nacional de Medicina, Buenos Aires, Argentina. ceg@ceg.com.ar
Acta Haematologica
|July 30, 2002
Abstract:
An inversion, inv(4)(p14q27), was found as the sole karyotypic anomaly at diagnosis in the bone marrow cells from a 65-year-old male patient with an M4 acute nonlymphocytic leukemia (ANLL). To our knowledge, the breakpoints observed in this case appear to be different from other inversions of chromosome 4 previously described in ANLL. The patient we described had a poor response to chemotherapy and had a short survival.