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Related Experiment Videos

Glyceryl trinitrate ointment in angina pectoris.

H H Salem, S P Singh

    Postgraduate Medical Journal
    |December 1, 1979
    PubMed
    Summary

    Topical glyceryl trinitrate (GTN) ointment effectively relieved chest pain in most angina pectoris patients. This long-acting nitrate preparation improved exercise capacity, offering a valuable treatment option when other therapies fail.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Dermatology

    Background:

    • Skin absorption of glyceryl trinitrate (GTN) is a known phenomenon.
    • Angina pectoris remains a significant cardiovascular condition requiring effective management.

    Purpose of the Study:

    • To assess and compare the efficacy of topical glyceryl trinitrate (GTN) ointment versus placebo in preventing chest pain.
    • To evaluate the impact of GTN on exercise capacity in patients with angina pectoris.

    Main Methods:

    • A study involving 17 patients diagnosed with angina pectoris.
    • Comparison of a GTN ointment against a placebo ointment.
    • Assessment of exercise capacity using a bicycle ergometer.

    Main Results:

    • The placebo cream showed no significant effect.
    • GTN ointment provided pain relief in 16 out of 17 patients.
    • Improved exercise capacity without chest pain was observed.
    • The beneficial effects of GTN lasted up to 3 hours in 12 patients.

    Conclusions:

    • Topical GTN ointment acts as an effective long-acting nitrate for angina relief.
    • This preparation is a potentially valuable therapeutic option for patients unresponsive or intolerant to beta-blockers or when surgery is not feasible.

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