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Related Experiment Videos

A fasting-induced decrease in plasma glucose concentration does not affect the insulin response to ingested protein

Asad Saeed1, Sidney A Jones, Frank Q Nuttall

  • 1Metabolic Research Laboratory, Section of Endocrinology, Metabolism, and Nutrition, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA.

Metabolism: Clinical and Experimental
|July 30, 2002
PubMed
Summary
This summary is machine-generated.

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People with type 2 diabetes show a similar insulin response to protein, regardless of initial blood glucose levels. This suggests higher glucose is not the sole reason for increased insulin sensitivity to protein in this population.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Nutritional Science

Background:

  • Individuals with type 2 diabetes exhibit heightened insulin sensitivity to protein compared to glucose.
  • In non-diabetic individuals, protein is significantly less potent than glucose in stimulating insulin secretion.

Purpose of the Study:

  • To investigate if elevated plasma glucose concentrations in type 2 diabetes contribute to the increased insulin response to protein.
  • To test the hypothesis that higher baseline glucose levels are responsible for the enhanced insulinogenic effect of protein.

Main Methods:

  • Seven males with untreated type 2 diabetes consumed 50g of lean beef after an overnight fast.
  • On a separate occasion, subjects underwent an additional 24-hour fast to reduce plasma glucose before consuming 50g of protein.

Related Experiment Videos

  • Insulin and glucose levels were measured following protein ingestion under both fasting conditions.

    • Main Results:

    • Fasting for an additional 24 hours successfully lowered plasma glucose concentrations before protein intake.
    • Despite a ~15% reduction in plasma glucose, the insulin response to protein ingestion remained nearly identical.
    • A modest, unexpected increase in glucose was observed after protein intake following the extended fast.

    Conclusions:

    • The enhanced insulin response to ingested protein in type 2 diabetes is unlikely to be solely due to higher initial plasma glucose concentrations.
    • This finding suggests other mechanisms may underlie the altered protein-glucose-insulin dynamics in type 2 diabetes.