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Related Experiment Videos

[Vitamin D and pregnancy].

Bernard-Louis Salle1, Edgar Delvin, Francis Glorieux

  • 1Hôpital E. Herriot, Service de néonatalogie, Place d'Arsonval, 69437 Lyon.

Bulletin De L'Academie Nationale De Medecine
|July 31, 2002
PubMed
Summary

Maternal vitamin D levels are crucial during pregnancy. Supplementation is necessary to prevent adverse effects on fetal development and newborn health, ensuring adequate calcium absorption and bone mineralization.

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Nutritional Science

Context:

  • Maternal serum 25-hydroxyvitamin D levels correlate with dietary intake during pregnancy.
  • Elevated 1.25-dihydroxyvitamin D, the active form, is synthesized by the placenta, enhancing calcium absorption.
  • The fetus relies entirely on maternal 25-hydroxyvitamin D, which readily crosses the placenta.

Purpose:

  • To highlight the importance of vitamin D status during pregnancy.
  • To underscore the role of placental synthesis of active vitamin D.
  • To emphasize the fetal dependence on maternal vitamin D supply.

Summary:

  • Vitamin D deficiency in pregnant individuals leads to decreased birth weight, impaired fetal bone mineralization, and neonatal hypocalcemia.
  • The placenta plays a key role in vitamin D metabolism and calcium absorption for fetal development.
  • Maternal vitamin D supplementation is essential, particularly in regions with low dietary intake from fortified foods.

Impact:

  • Informing clinical practice regarding prenatal vitamin D screening and supplementation protocols.
  • Guiding public health initiatives for maternal and infant nutrition.
  • Contributing to the understanding of vitamin D's role in ensuring healthy fetal growth and neonatal outcomes.

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