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[Pathogenesis of pre-eclampsia: role of gamma PPAR in trophoblast invasion]

Danièle Evain-Brion1, Thierry Fournier, Patrice Therond

  • 1Institut National de la Santé et de la Recherche Médicale, U427, Université René Descartes, 4 avenue de l'Observatoire, 75006 Paris, France.

Bulletin De L'Academie Nationale De Medecine
|July 31, 2002
PubMed

Pre-eclampsia is a major complication of human pregnancy. Its trigger is from placental origin and may involve an abnormal placentation characterized by a defect of trophoblast invasion and an absence of remodelling of the maternal spiral arteries. In this study, we have characterized and developed a model of culture of extravillous trophoblast cells involved in human implantation. We showed that these cells expressed high levels of PPAR gamma by immunocytochemistry and real-time quantitative PCR. We showed that different natural ligands potentially present at the feto-maternal interface, such as oxidised low density lipoproteins, inhibited in vitro in a concentration dependent manner extravillous cytotrophoblast invasion. These results point to a key role of PPAR gamma in the pathology of pre-eclampsia.

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