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Updated: Aug 15, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
[Hyperstosis in patients with intracranial meningioma--secondary changes in tumor invasion]
Abstract:
A comprehensive clinical, histological, and immunohistochemical evaluation was done of 42 intracranial meningiomas in patients with hyperostosis in the postoperative period. It has been ascertained that hyperostosis in meningiomas is a direct bone tumour invasion. Bone invasion is not a sign of malignant transformation of meningiomas. It is shown that meningiomas with hyperostosis are hormone-dependent tumours. In tumours, there has been detected a high concentration of progesterone and estrogen active receptors. It is shown that hyperostosis is a consequence of hormone-related abnormalities of Ca metabolism. Special stress is laid on ridding the bone of hyperostosis at tumour removal to reduce the number of tumour recurrences.
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