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January 2002: 59-year-old woman with an intrasellar lesion
Volkmar H J Hans1, Horst Urbach, Rudolph A Kristof
1Institute for Neuropathology, University Hospital, Bonn, Germany.
Brain Pathology (Zurich, Switzerland)
|July 31, 2002
Abstract:
An intrasellar lesion resembling a hormone-inactive pituitary adenoma was resected in a 59-year-old woman. The well-differentiated benign tumor was composed of ganglion-like cells, clusters of adenohypophyseal tissue as well as a GH-expressing adenoma. In addition, small cells exhibited an intermediate neuronal and epithelial immunoreactivity. Surrounding the tumor was a spindle cell component that histologically resembled Antoni A areas of a schwannoma, but showed a mixed immunohistochemical profile. Final diagnosis was intrasellar glioneuronal hamartoma with GH-cell pituitary adenoma.