Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropeptides and appetite control.

J P H Wilding1

  • 1Clinical Sciences Centre, University Hospital Aintree, Longmoor lane, Liverpool L9 7AL, Liverpool, UK. j.p.h.wilding@liv.ac.uk

Diabetic Medicine : a Journal of the British Diabetic Association
|July 31, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Peripheral Neuropathy Prevalence and Characteristics Are Comparable in People with Obesity and Long-Duration Type 1 Diabetes.

Advances in therapy·2022
Same author

Mechanisms, screening modalities and treatment options for individuals with non-alcoholic fatty liver disease and type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Correction to: Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C.

Diabetologia·2019
Same author

Beyond lifestyle interventions: exploring the potential of anti-obesity medications in the UK.

Clinical obesity·2018
Same author

Evaluation of Aintree LOSS, a community-based, multidisciplinary weight management service: outcomes and predictors of engagement.

Clinical obesity·2017
Same author

Arrhythmogenic gene remodelling in elderly patients with type 2 diabetes with aortic stenosis and normal left ventricular ejection fraction.

Experimental physiology·2017
Same journal

Prevalence, duration, and clinical implications of continuous glucose monitor measurement limit capping in type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Disentangling the effect of brain insulin resistance on brain health (BIR-BrainHealth): Rationale and study protocol.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Clinical characteristics and in-hospital mortality among insulin pump users with acute coronary syndrome in the predominantly open-loop era: A UK-wide MINAP registry analysis.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Hyperlipidaemia in youth with type 1 diabetes: Are current guidelines clinically useful?

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Hypoglycaemia care: Time to modernise our treatment standards.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Continuing automated insulin delivery systems during hospitalisation with type 1 diabetes: A thematic literature review.

Diabetic medicine : a journal of the British Diabetic Association·2026
See all related articles

Obesity significantly impacts type 2 diabetes development and management. Understanding the hormonal and neural signals controlling energy homeostasis, particularly leptin and neuropeptide Y, is key to developing new obesity treatments.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Metabolism

Background:

  • Obesity is a critical factor in type 2 diabetes etiology, hindering prevention and management.
  • Energy imbalance, where intake surpasses expenditure, drives obesity.
  • Complex hormonal and neural systems regulate energy homeostasis, but are predisposed to weight gain.

Purpose of the Study:

  • To explore the intricate mechanisms of energy homeostasis regulation.
  • To elucidate the role of hormonal and neural signals in controlling food intake and energy expenditure.
  • To highlight the significance of leptin and POMC in human obesity.

Main Methods:

  • Review of hormonal and neural signaling pathways involved in appetite regulation.
  • Analysis of the central nervous system's (CNS) role, particularly the hypothalamus, in integrating these signals.

Related Experiment Videos

  • Examination of the impact of low energy stores on neurotransmitter production and their effects on feeding behavior.

    • Main Results:

    • Short-term signals (e.g., cholecystokinin, ghrelin) and long-term signals (e.g., insulin, leptin) converge in the hypothalamus.
    • Hypothalamic pathways strongly promote food intake and decrease energy expenditure when energy stores are low.
    • Reduced leptin levels trigger increased production of appetite-stimulating neurotransmitters (NPY, galanin, AGRP) and decreased levels of appetite-suppressing ones (alpha-MSH, CART, neurotensin).

    Conclusions:

    • Mutations in leptin and POMC are linked to severe early-onset obesity in humans.
    • Understanding these appetite regulation pathways offers potential for novel obesity treatments.
    • These advancements could significantly benefit the prevention and management of type 2 diabetes.