Feline injection site sarcomas

Feline injection site sarcomas have mostly been associated with the administration of vaccines. Although the pathogenesis remains largely unknown, it is believed the inflammatory reaction caused by the injection of the compound leads to uncontrolled proliferation of fibroblasts and myofibroblasts that may undergo malignant transformation in a subset of cats. Pretreatment evaluation and proper planning of therapy are essential. Currently, because of the aggressive nature of these tumors, a multimodality treatment approach is recommended.