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Updated: Jul 31, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Simple parameterization of non-proteinogenic amino acids for QSAR of antibacterial peptides
Tore Lejon1, John S Svendsen, Bengt E Haug
1Department of Chemistry, University of Tromsø, Norway. tore.lejon@chem.uit.no
Abstract:
The antibacterial activity of bovine lactoferricin-(17-31)-pentadecapeptide against Escherichia coli and Staphylococcus aureus is sensitive to substitution of the Trp residues, and synthetic peptides with phenylalanine and any of eight non-proteinogenic aromatic amino acids greatly affected antibiotic activity. Using simple size-related descriptors for the new amino acids it is possible to develop quantitative structure-activity relationships (QSARs) that can be used as tools in the search for more active peptides.
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