Related Experiment Videos
Enhancing bowel adaptation in short bowel syndrome
Palle Bekker Jeppesen1, Per Brobech Mortensen
1Department of Medicine CA-2121, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Bekker@dadlnet.dk
Current Gastroenterology Reports
|August 1, 2002
Summary
Intestinal failure, often requiring parenteral support, can improve through intestinal adaptation after resection. Research explores optimizing remnant intestinal function with growth hormone, glutamine, or glucagon-like peptide-2 to enhance nutrient absorption.
Area of Science:
- Gastroenterology and Nutrition
- Surgical Recovery and Adaptation
Background:
- Malabsorption of nutrients, fluids, and electrolytes can lead to deficiencies if not compensated.
- Intestinal failure is defined by the need for parenteral support to maintain nutritional balance.
- Intestinal adaptation is a key process for recovery following intestinal resection.
Purpose of the Study:
- To describe factors influencing morphologic and functional changes during intestinal adaptation.
- To present results from clinical trials on interventions for short bowel patients.
Main Methods:
- Review of factors affecting intestinal adaptation.
- Presentation of clinical trial data for growth hormone, glutamine, and glucagon-like peptide-2.
Main Results:
- Factors influencing the morphologic and functional changes in adaptation are detailed.
- Clinical trial results for specific interventions in short bowel patients are provided.
Conclusions:
- Understanding intestinal adaptation is crucial for managing intestinal failure.
- Interventions like growth hormone, glutamine, and glucagon-like peptide-2 show potential in optimizing remnant intestinal function.