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Related Experiment Videos

Complement's participation in acquired immunity.

Claus Henrik Nielsen1, Robert Graham Quinton Leslie

  • 1Institute for Inflammation Research, Rigshospitalet, University Hospital Copenhagen, Denmark.

Journal of Leukocyte Biology
|August 1, 2002
PubMed
Summary

Complement regulates B cell functions like antibody production and antigen presentation. Its role in acquired immunity and autoimmune responses is mediated by the B cell receptor signaling triad.

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Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Complement system's involvement in humoral immunity has been recognized for decades.
  • Recent advances have elucidated the detailed mechanisms of complement's regulatory functions in B cells.

Purpose of the Study:

  • To review the current understanding of complement's role in acquired immunity.
  • To discuss complement's regulation of autoimmune responses.

Main Methods:

  • Review of existing literature on complement and B cell function.
  • Analysis of signaling pathways involving the B cell receptor (BCR), complement receptor 2 (CR2, CD21), CD19, and FcgammaRIIb (CD32).

Main Results:

  • Complement regulates key B cell functions: antibody production, antigen uptake, processing, presentation, and repertoire shaping.
  • The B cell signaling triad (BCR, CR2/CD19, FcgammaRIIb) integrates signals determining immune response outcomes.
  • Antigen context (alone or with antibodies/complement fragments) dictates signaling through the triad.

Conclusions:

  • Complement is a critical regulator of adaptive immune responses.
  • Understanding complement's role is vital for managing autoimmune diseases.

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