Neuronal polarity: microtubules strike back

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Proteomic analysis reveals early pathological defects in corticospinal motor neurons of a spastin model of hereditary spastic paraplegia, which are improved by NU-9 treatment.

Neurobiology of disease·2026

Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.

Cell reports·2026

Big Tau: Structure, Evolutionary Divergence, and Emerging Roles in Cytoskeletal Dynamics and Tauopathies.

Cells·2026

Intracerebroventricular SPAST-AAV9 gene therapy prevents manifestation of symptoms in a mouse model of SPG4 hereditary spastic paraplegia.

Molecular therapy : the journal of the American Society of Gene Therapy·2025

Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation.

Frontiers in molecular neuroscience·2025

The glycolytic enzyme PGAM1 functions as a metabolic-autophagy checkpoint to coordinate growth and stress tolerance.

Nature cell biology·2026

Mitochondrial-derived vesicles drive budding-type fission of damaged lysosomes.

Nature cell biology·2026

Lysosomes and lysosomal dysfunction in ageing biology.

Nature cell biology·2026

Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression.

Nature cell biology·2026

Decoding stage-specific functions of PRC2 in early embryogenesis uncovers roles in preimplantation development and primordial germ cell fate.

Nature cell biology·2026

Dynamic control of nucleotide metabolism in physiology and disease.

Nature cell biology·2026

["Noise" in brain electrical activity. I. Basic research findings, cognitive processes].

Ideggyogyaszati szemle·2026

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.

Nature neuroscience·2026

Accelerated, Neuronavigated Neuromodulation for Negative Symptoms in Schizophrenia: Protocol for a Randomized Controlled Pilot Trial.

Sante mentale au Quebec·2026

Deletion of neuroligins from astrocytes does not detectably alter synapse numbers or astrocyte cytoarchitecture by maturity.

eLife·2026

Caveola and Its Resident Proteins, Caveolin-1 and -2, Play Critical Roles in the Pathogenesis of nAMD and PCV.

Investigative ophthalmology & visual science·2026

Anorexia Nervosa, Schizophrenia, and Autism Spectrum Disorder: A Review of the Role of Tanycytes in Individual and Social Behavior.

Cureus·2026

Related Experiment Videos

Neuronal polarity: microtubules strike back

Related Concept Videos

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Proteomic analysis reveals early pathological defects in corticospinal motor neurons of a spastin model of hereditary spastic paraplegia, which are improved by NU-9 treatment.

Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.

Big Tau: Structure, Evolutionary Divergence, and Emerging Roles in Cytoskeletal Dynamics and Tauopathies.

Intracerebroventricular SPAST-AAV9 gene therapy prevents manifestation of symptoms in a mouse model of SPG4 hereditary spastic paraplegia.

Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation.

The glycolytic enzyme PGAM1 functions as a metabolic-autophagy checkpoint to coordinate growth and stress tolerance.

Mitochondrial-derived vesicles drive budding-type fission of damaged lysosomes.

Lysosomes and lysosomal dysfunction in ageing biology.

Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression.

Decoding stage-specific functions of PRC2 in early embryogenesis uncovers roles in preimplantation development and primordial germ cell fate.

Dynamic control of nucleotide metabolism in physiology and disease.

["Noise" in brain electrical activity. I. Basic research findings, cognitive processes].

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.

Accelerated, Neuronavigated Neuromodulation for Negative Symptoms in Schizophrenia: Protocol for a Randomized Controlled Pilot Trial.

Deletion of neuroligins from astrocytes does not detectably alter synapse numbers or astrocyte cytoarchitecture by maturity.

Caveola and Its Resident Proteins, Caveolin-1 and -2, Play Critical Roles in the Pathogenesis of nAMD and PCV.

Anorexia Nervosa, Schizophrenia, and Autism Spectrum Disorder: A Review of the Role of Tanycytes in Individual and Social Behavior.

Related Experiment Videos

Neuronal polarity: microtubules strike back

Related Concept Videos

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