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Multiple intrahepatic biliary cysts in children with biliary atresia
Ling-Nan Bu1, Huey-Ling Chen, Yen-Hsuan Ni
1Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Journal of Pediatric Surgery
|August 1, 2002
Summary
Multiple intrahepatic biliary cysts are a common complication in patients with biliary atresia, indicating a poorer prognosis. Antibiotic treatment is recommended for biliary infection signs.
Area of Science:
- Hepatology
- Pediatric Surgery
- Gastroenterology
Background:
- Biliary atresia is a serious neonatal liver disease.
- Intrahepatic biliary cysts can be a complication.
- Understanding their incidence and impact is crucial.
Purpose of the Study:
- To determine the incidence of intrahepatic biliary cysts in biliary atresia patients.
- To analyze the clinical course and outcomes of these cysts.
- To investigate the specific characteristics of multiple intrahepatic cysts.
Main Methods:
- A cohort of 154 biliary atresia patients were studied between 1992 and 2000.
- Abdominal ultrasonography was used for routine examination and follow-up.
- Clinical data, including jaundice and cholangitis history, were recorded.
Main Results:
- The overall incidence of intrahepatic cysts was 25.3%, with multiple cysts found in 10.4% of patients.
- Patients with multiple cysts frequently presented with jaundice (81.3%) and a history of cholangitis (93.8%).
- Multiple cysts were associated with a higher mortality rate compared to single cysts (P=.037).
Conclusions:
- Multiple intrahepatic biliary cysts are a significant complication in biliary atresia.
- Their presence suggests a poorer prognosis for affected patients.
- Prolonged parenteral antibiotic therapy is advised for biliary infection.