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Insulin therapy in type 2 diabetes.

R Keith Campbell1, John R White

  • 1College of Pharmacy, Washington State University, Pullman 99164-6510, USA. rkcamp@wsu.edu

Journal of the American Pharmaceutical Association (Washington, D.C. : 1996)
|August 2, 2002
PubMed
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Early insulin therapy for type 2 diabetes improves long-term glycemic control and corrects underlying abnormalities. Patients should view insulin initiation as a positive step for better health outcomes.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Pharmacology

Background:

  • Type 2 diabetes management is evolving with increased insulin use.
  • Traditional treatment paradigms often delay insulin initiation.

Purpose of the Study:

  • To review the current use of insulin therapy in type 2 diabetes.
  • To outline practical considerations for initiating insulin treatment.

Main Methods:

  • Literature search of MEDLINE (1995-2001) for relevant studies.
  • Review of randomized controlled trials, focusing on insulin analogs.
  • Analysis of studies comparing insulin lispro, insulin aspart, and insulin glargine.

Main Results:

  • Early insulin therapy can correct pathogenetic abnormalities and improve long-term glycemic control.

Related Experiment Videos

  • Modern insulin regimens, including analogs like insulin glargine, lispro, and aspart, mimic natural insulin secretion.
  • Insulin analogs offer improved flexibility and efficacy in managing blood glucose levels.

    • Conclusions:

    • Initiating insulin therapy early in type 2 diabetes is beneficial for long-term health.
    • Insulin therapy should be viewed as a positive treatment advancement, not a disease progression indicator.