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Related Experiment Videos

Laryngeal sarcoidosis.

Carole M Dean1, Robert Thayer Sataloff, Mary J Hawkshaw

  • 1Department of Otolaryngology--Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Journal of Voice : Official Journal of the Voice Foundation
|August 2, 2002
PubMed
Summary

Laryngeal sarcoidosis, a rare manifestation of this chronic granulomatous disease, can cause airway obstruction. Inhaled steroids showed promise in treating a patient with this condition, suggesting a potential new therapeutic avenue.

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Area of Science:

  • Pulmonology
  • Otolaryngology
  • Immunology

Background:

  • Sarcoidosis is a systemic granulomatous disease affecting multiple organs, including the lungs, liver, and skin.
  • Laryngeal involvement is less common but can lead to significant symptoms like hoarseness, dysphagia, and dyspnea.
  • Existing treatments for laryngeal sarcoidosis include steroids, radiation, and surgery, with an autoimmune etiology suggested.

Observation:

  • A patient with laryngeal sarcoidosis experienced significant and lasting improvement.
  • This improvement occurred after the patient was prescribed inhaled steroids for co-existing obstructive pulmonary disease.
  • The patient's laryngeal sarcoidosis responded well to this novel treatment approach.

Findings:

  • Inhaled corticosteroids may be an effective treatment for laryngeal sarcoidosis.

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  • This represents a potentially less invasive and more accessible treatment option compared to traditional methods.
  • The patient demonstrated sustained symptom relief and functional improvement.

    • Implications:

    • Further clinical investigation into inhaled steroids for laryngeal sarcoidosis is warranted.
    • This approach could offer a new therapeutic strategy for managing this rare condition.
    • Understanding the role of inhaled steroids may shed light on the underlying pathophysiology of laryngeal sarcoidosis.