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Intratympanic ciprofloxacin and the human labyrinthine sampling model
Zoran Becvarovski1, Jack M Kartush, Dennis I Bojrab
1Michigan Ear Institute, Farmington Hills, USA. zb@ent.com.au
The Laryngoscope
|August 2, 2002
Summary
Intratympanic ciprofloxacin did not absorb into the inner ear fluid or systemic circulation in patients. This suggests a low risk of ototoxicity from ciprofloxacin, even with a perforated eardrum.
Area of Science:
- Otolaryngology
- Pharmacology
- Neurosurgery
Background:
- Intratympanic antibiotics are used for middle ear infections and prophylaxis.
- Ciprofloxacin is a fluoroquinolone antibiotic with potential ototoxic effects.
- Understanding drug absorption is crucial for safety and efficacy.
Purpose of the Study:
- To evaluate the absorption of intratympanic ciprofloxacin across the human round window membrane.
- To determine if ciprofloxacin penetrates the inner ear following middle ear administration.
Main Methods:
- Prospective study involving 10 patients undergoing acoustic tumor removal.
- Ciprofloxacin (0.3%) instilled into the middle ear.
- Labyrinthine fluid, cerebrospinal fluid, and serum samples collected and analyzed for ciprofloxacin.
Main Results:
- No measurable ciprofloxacin was detected in labyrinthine fluid, cerebrospinal fluid, or serum.
- Sampling occurred between 9 and 120 minutes post-administration.
Conclusions:
- Intratympanic ciprofloxacin does not appear to be absorbed into the inner ear or systemic circulation via the round window membrane.
- This lack of absorption suggests a low risk of ciprofloxacin-induced ototoxicity, even with tympanic membrane perforations.