Related Experiment Videos
Amplifying mechanisms of lymphomagenesis
1Howard Hughes Medical Institute and Department of Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Molecular Cell
|August 2, 2002
Abstract:
Mice doubly deficient for either XRCC4 or DNA ligase IV and p53 invariably develop lymphomas bearing characteristic chromosome translocations with gene amplification. A recent study highlights the importance of nonclassical end joining mechanisms in the formation of these oncogenic DNA rearrangements.