Investigation of 4,5-epoxymorphinan degradation during analysis by HPLC
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Updated: Sep 30, 2026
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Mary Ann Quarry1, Dolores S Sebastian, Frank Diana
1DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880, USA. maquarry@alum.villanova.edu
Abstract:
Compounds of the 4,5-epoxymorphinan series have been shown to degrade in solution to the corresponding 2,2'-dimers when stored in amber glass HPLC vials. A colorant in the glass has been shown to catalyze the degradation. Although amber glass is routinely used to protect solutions from light degradation, it should not be used without evaluating its effect on sample stability.
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