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Molecular cloning and expression analysis of MPP alpha-2, a novel mouse transcript detected in a differential screen
Toshinobu Miyamoto1, Maria T Fiorenza, Yangu Zhao
1Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Biochimica Et Biophysica Acta
|August 2, 2002
Abstract:
We identified a novel isoform transcript, MPP alpha-2, of the mouse Mg(2+)-dependent protein phosphatase (MPP) alpha gene. The amino acid sequence encoded by MPP alpha-2 differs from the previously known MPP alpha-1 sequence only at the carboxyl terminal region. Northern and in situ hybridization analysis revealed differential expression patterns of these two transcripts in the embryo and in the adult organism, suggesting an elaborate regulation of the MPP alpha gene.