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The effect of beta-carotene on lung and skin carcinogenesis
1Department of Nutritional Sciences and Toxicology, University of California, Berkeley CA 94720-3104, USA. retinol@nature.berkeley.edu
Carcinogenesis
|August 2, 2002
Abstract:
The induction of pre-cancerous squamous metaplasia in lungs of ferrets by high doses of dietary beta-carotene (BC) and cigarette smoke is compared with and contrasted to the different effects of high doses of dietary BC on skin papilloma and carcinoma induction by the two-stage carcinogenesis protocol. Whereas high dietary BC can inhibit the conversion of skin papillomas to carcinomas, such treatment would not be expected to inhibit smoke-induced lung tumors.