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Semen alterations in HIV-1 infected men
E Dulioust1, A Le Du, D Costagliola
1Laboratoire de Biologie de la Reproduction, GREFH, Hôpital Cochin-APHP, Université Paris 5, 123 Bd de Port Royal, 75014 Paris, France. emmanuel.dulioust@cch.ap-hop-paris.fr
Human Reproduction (Oxford, England)
|August 2, 2002
Summary
HIV-infected men seeking assisted reproductive technology (ART) show significantly altered semen quality, including reduced sperm motility and count. These changes may be linked to antiretroviral therapies, impacting male fertility.
Area of Science:
- Reproductive Medicine
- Virology
- Andrology
Background:
- Couples with male human immunodeficiency virus (HIV) infection increasingly utilize assisted reproductive technology (ART) for safe procreation.
- Semen quality is a critical factor for successful ART outcomes in these couples.
Purpose of the Study:
- To evaluate semen characteristics in a large cohort of HIV-infected men undergoing ART.
- To identify specific alterations in semen parameters associated with HIV infection and its treatment.
Main Methods:
- Semen analysis was performed on 189 HIV-infected men seeking ART, with most on antiretroviral therapy.
- Comparisons were made with age- and abstinence-matched HIV-seronegative men.
Main Results:
- HIV-infected men exhibited significantly lower percentages of rapidly progressive sperm (10% vs. 15%) and higher concentrations of non-spermatic cells (3 x 10^6/ml vs. 1.1 x 10^6/ml).
- Reduced ejaculate volume (2.8 ml vs. 3.6 ml) and total sperm counts (262.5 x 10^6 vs. 310.5 x 10^6) were also observed.
Conclusions:
- Semen evaluation reveals significant alterations in HIV-infected men seeking ART.
- Observed semen anomalies may be associated with antiretroviral treatments.