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Related Experiment Video

Updated: Feb 12, 2026

Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism

Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism

Published on: October 3, 2018

Risperidone in children with autism and serious behavioral problems.

James T McCracken¹, James McGough, Bhavik Shah

¹University of California, Los Angeles, USA.

The New England Journal of Medicine

|August 2, 2002

Summary

Risperidone effectively treated severe behavioral disturbances in children with autistic disorder, significantly reducing irritability and aggression. Benefits were maintained for six months, though short-term adverse effects like weight gain were noted.

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Area of Science:

Child and Adolescent Psychiatry
Neuropharmacology
Developmental Disorders

Background:

Atypical antipsychotics, targeting dopamine and serotonin receptors, show promise for treating behavioral disturbances in children with autistic disorder.
Limited data exists on the safety and efficacy of these agents in pediatric populations.

Purpose of the Study:

To evaluate the efficacy and safety of risperidone compared to placebo in children aged 5-17 with autistic disorder and severe behavioral issues.
To assess changes in irritability and overall clinical improvement.

Main Methods:

A multisite, randomized, double-blind trial involving 101 children with autistic disorder.
Primary outcomes measured using the Aberrant Behavior Checklist Irritability subscale and Clinical Global Impressions - Improvement scale over eight weeks.

Main Results:

Risperidone significantly reduced irritability scores by 56.9% versus 14.1% for placebo (P<0.001).
A 69% positive response rate was observed with risperidone compared to 12% with placebo (P<0.001).
Common side effects included weight gain, increased appetite, fatigue, and drowsiness; benefits were maintained in two-thirds of responders at six months.

Conclusions:

Risperidone is effective and generally well-tolerated for managing tantrums, aggression, and self-injurious behavior in children with autistic disorder.
Longer-term studies are needed to fully assess potential adverse effects like tardive dyskinesia.