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Comparative evaluation of the new Sheffield table and the modified joint British societies coronary risk prediction
K S Rabindranath1, N R Anderson, R Gama
1Department of Medicine, New Cross Hospital, Wolverhampton, West Midlands, UK.
Insights
The new Sheffield table and modified Joint British Societies (JBS) coronary heart disease (CHD) risk charts demonstrate high accuracy in primary care. Both tools are reliable for assessing patient risk, allowing clinicians to choose based on preference.
Area of Science:
- Cardiology
- Preventive Medicine
- Health Informatics
Background:
- Coronary heart disease (CHD) risk assessment guides management of borderline hypertension and hypercholesterolemia.
- Traditional CHD risk prediction relies on Framingham equations, often simplified by tools like the Sheffield table and Joint British Societies (JBS) chart.
- Simplifications in these charts, such as dichotomizing blood pressure or approximating age, may impact diagnostic accuracy.
Purpose of the Study:
- To evaluate and compare the diagnostic performance of the new Sheffield table and the modified JBS chart.
- To assess these tools against individualized, laboratory-based CHD risk calculations.
Main Methods:
- Diagnostic performance evaluation of two CHD risk assessment tools.
- Comparison against a laboratory-based CHD risk calculation.
- Study conducted on 1102 subjects in a primary care setting.
Main Results:
- Both the new Sheffield table and modified JBS chart exhibited high diagnostic accuracy, with similar sensitivity and specificity at 10-year CHD risk thresholds of 15% and 30%.
- The modified JBS chart offers a graded risk display, potentially advantageous over the Sheffield table's threshold identification.
- The Sheffield table uniquely functions as a screening tool for cholesterol measurement.
Conclusions:
- The new Sheffield table and modified JBS chart are validated for primary care use, with diagnostic accuracy unaffected by approximations in age and blood pressure.
- Clinicians are advised to select the risk assessment tool they are most comfortable using.
- Both tools provide reliable CHD risk assessment in primary care settings.
Background:
Management of borderline hypertension and hypercholesterolaemia is based on an individual's coronary heart disease (CHD) risk rather than arbitrary values for blood pressure or serum cholesterol. Prediction of CHD risk involves using tables, charts, or computer programs based on the Framingham equations. The new Sheffield table and modified joint British societies coronary risk prediction (JBS) chart are widely used. The JBS chart approximates age and systolic blood pressure, and the new Sheffield table dichotomises blood pressure, and these simplifications may lead to diagnostic inaccuracy.
Methods:
The diagnostic performance of the charts against an individualised laboratory based CHD risk calculation in 1102 subjects in primary care were evaluated and compared.
Results:
The new Sheffield table and modified JBS chart performed equally well with a respective diagnostic sensitivity and specificity of 91.6% (95% confidence interval 86.7% to 95.1%) and 93.8% (91.1% to 97.9%), and 93.6% (90.4% to 96.0%) and 94.7% (92.6% to 96.1%) at 10 year CHD risk of 15%; and of 95.2% (82.8% to 99.4%) and 97.9% (96.8% to 98.7%), and 90.5% (75.6% to 97.4%) and 100% (99.7% to 100%) at 10 year CHD risk of 30%. The modified JBS chart graphic display provides graded risk, which may be an advantage over the new Sheffield table, which identifies thresholds of risk. The new Sheffield table, unlike any other method, can be used as screening tool for cholesterol measurement.
Conclusions:
The new Sheffield table and modified JBS chart are valid for use in primary care since their diagnostic accuracy is unaffected by approximations in age and blood pressure. It is suggested that practitioners should choose whichever risk assessment tool they are comfortable with and use it.
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