Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic sclerosis and occupational risk factors: a case-control study.

E Diot1, V Lesire, J L Guilmot

  • 1INSERM EMI-U 00-10, Groupe de Pneumologie, CHU Bretonneau, 2 bd Tonnellé, F-37044 Tours Cedex 1, France. ediot@med.univ-tours.fr

Occupational and Environmental Medicine
|August 2, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Job-exposure matrix (JEM) validity on crystalline silica among systemic sclerosis patients.

Occupational medicine (Oxford, England)·2025
Same author

Large-vessel involvement in ANCA-associated vasculitis: A multicenter case-control study.

Seminars in arthritis and rheumatism·2024
Same author

[Popliteal pain of unusual cause].

La Revue de medecine interne·2023
Same author

[Characteristics of patients with connective tissue disease-associated pulmonary arterial hypertension treated with prostanoids: A multicenter retrospective study].

La Revue de medecine interne·2021
Same author

Lack of essential medical resources leaves Africa breathless.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
Same author

Giant cell arteritis-related aortitis with positive or negative temporal artery biopsy: a French multicentre study.

Scandinavian journal of rheumatology·2019

Occupational exposure to silica and solvents like trichlorethylene is linked to systemic sclerosis (SS). This study highlights key environmental risk factors contributing to the development of SS.

Area of Science:

  • Environmental Medicine
  • Occupational Health
  • Rheumatology

Background:

  • Systemic sclerosis (SS) is a complex autoimmune disease with known environmental triggers.
  • Understanding occupational exposures is crucial for identifying preventable risk factors for SS.

Purpose of the Study:

  • To investigate the association between occupational exposures and the development of systemic sclerosis (SS).
  • To identify specific workplace agents contributing to SS risk.

Main Methods:

  • A case-control study involving 80 systemic sclerosis patients and matched controls was conducted.
  • Occupational exposure to silica dust and various organic solvents was assessed retrospectively by expert review.
  • A cumulative exposure score was calculated based on probability, intensity, and duration of exposure.

Related Experiment Videos

Main Results:

  • Significant associations were found between SS and exposure to crystalline silica, trichlorethylene, chlorinated solvents, toluene, aromatic solvents, ketones, white spirit, epoxy resins, and welding fumes.
  • High cumulative exposure scores for crystalline silica, trichlorethylene, chlorinated solvents, welding fumes, and overall solvents significantly increased SS risk.

Conclusions:

  • Occupational factors, including silica and various solvents, play a significant role in the etiology of systemic sclerosis.
  • These findings underscore the importance of controlling workplace exposures to prevent SS.