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Related Experiment Videos

Memory function during propofol and alfentanil anesthesia: predictive value of individual differences.

Chantal Kerssens1, Gitta H Lubke, Jan Klein

  • 1Department of Anesthesiology, University Hospital Rotterdam, The Netherlands. kerssens@mpp.fgg.eur.nl

Anesthesiology
|August 2, 2002
PubMed
Summary

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During deep sedation (BIS 60-70), weak explicit memory function was observed, particularly in patients with better preoperative memory. This suggests awareness during anesthesia influences postoperative memory, though the exact relationship requires further study.

Area of Science:

  • Anesthesiology
  • Neuroscience
  • Cognitive Psychology

Background:

  • Conscious recall and implicit memory are influenced by hypnotic state, measured by electroencephalographic (EEG) bispectral index (BIS).
  • Unconscious-controlled memory has been observed during moderate to light sedation (BIS 70-80).
  • This study explored memory function during deep sedation (BIS 60-70).

Purpose of the Study:

  • To investigate memory function during deep sedation (BIS 60-70).
  • To identify predictors of individual differences in memory performance during deep sedation.
  • To distinguish explicit from implicit memory effects under deep sedation.

Main Methods:

  • Assessed memory and information processing speed in 56 outpatients before surgery.
  • Administered propofol anesthesia with alfentanil, titrated to BIS 60-70.

Related Experiment Videos

  • Used the Isolated Forearm Technique to assess response to command and a process dissociation procedure for memory testing.

    • Main Results:

    • Mean BIS was 64.0 +/- 3 during word presentation.
    • Evidence of memory was found via process dissociation (inclusion hit rate 0.26 vs. exclusion 0.12) in some patients.
    • Memory scores correlated with preoperative memory test scores (r = 0.35).

    Conclusions:

    • Weak explicit memory function exists during anesthesia titrated to BIS 60-70.
    • Postoperative memory appears related to intraoperative awareness, but the precise nature of this link is unclear.
    • Patients with better preoperative memory may be more likely to exhibit memory effects during sedation.