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Corticosteroid responsive fludarabine pulmonary toxicity
George S Stoica1, Harly E Greenberg, Leonard J Rossoff
1Division of Pulmonary and Critical Care Medicine, Long Island Jewish Medical Center, New Hyde Park, New York 11042-1101, U.S.A.
American Journal of Clinical Oncology
|August 2, 2002
Abstract:
Fludarabine monophosphate is a purine nucleoside antimetabolite with efficacy in the treatment of lymphoproliferative disorders and chronic lymphocytic leukemia. It is the 2-fluoro, 5' phosphate derivative of 9-beta-D-arabinofuranosyl adenine (ara-A, vidarabine) and the mechanism of action is through inhibition of DNA synthesis and the cytolytic effects through the induction of endonuclease-independent apoptosis.