Protect the killer: CTLs need defenses against the tumor

UV irradiation drives lineage-specific MITF-mediated transcription of PD-L1 to confer immune tolerance to UV-mutated melanocytes.

Immunity·2026

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis.

eLife·2026

Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors.

bioRxiv : the preprint server for biology·2026

Dissecting the Tumor Microenvironment to Identify Biomarkers of Outcome to Anti-PD-1 Therapy in Clear-Cell Renal Cell Carcinoma: Analyses of the HCRN GU16-260 Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infection.

Proceedings of the National Academy of Sciences of the United States of America·2026

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy.

bioRxiv : the preprint server for biology·2026

Dual antithrombotic therapy using potent antiplatelet inhibitors in atrial fibrillation and acute coronary syndrome: a randomized controlled trial.

Nature medicine·2026

Induced pluripotent stem cells from discovery to translation.

Nature medicine·2026

CD19 CAR T cell therapy for treatment-refractory seropositive rheumatoid arthritis: a phase 1 trial.

Nature medicine·2026

A multi-faceted hospital-based intervention for intrapartum care in sub-Saharan Africa: a stepped-wedge cluster-randomized trial.

Nature medicine·2026

Recombinant shingles vaccination and the risk of cardiovascular events.

Nature medicine·2026

Oligodendrocyte dysfunction in human age-related cognitive decline.

Nature medicine·2026

Two exemplary cases of minimal and extensive dismemberment.

Legal medicine (Tokyo, Japan)·2026

Individual-Level Interventions for Alcohol-Related Harm in Night-Time Entertainment Precincts: A Scoping Review.

Drug and alcohol review·2026

Remodeling lipid and mitochondrial homeostasis: a novel mechanism by which polydatin attenuates renal tubular senescence in chronic kidney disease.

International immunopharmacology·2026

Risk perception and spatial mobility on the Camino de Santiago: travel patterns analysis and the choice of Jacobean routes.

Frontiers in psychology·2026

Breaking the Chain: HIV-1 Transmission Clusters among People who Inject Drugs in North Carolina, 2010 to 2023.

Journal of acquired immune deficiency syndromes (1999)·2026

Timely provisional surveillance of suicides using data from CDC's National Violent Death Reporting System: a cross-sectional analysis of data from 50 US states, the District of Columbia and Puerto Rico, January-June 2024.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2026

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Protect the killer: CTLs need defenses against the tumor

Related Concept Videos

UV irradiation drives lineage-specific MITF-mediated transcription of PD-L1 to confer immune tolerance to UV-mutated melanocytes.

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis.

Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors.

Dissecting the Tumor Microenvironment to Identify Biomarkers of Outcome to Anti-PD-1 Therapy in Clear-Cell Renal Cell Carcinoma: Analyses of the HCRN GU16-260 Trial.

Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infection.

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy.

Dual antithrombotic therapy using potent antiplatelet inhibitors in atrial fibrillation and acute coronary syndrome: a randomized controlled trial.

Induced pluripotent stem cells from discovery to translation.

CD19 CAR T cell therapy for treatment-refractory seropositive rheumatoid arthritis: a phase 1 trial.

A multi-faceted hospital-based intervention for intrapartum care in sub-Saharan Africa: a stepped-wedge cluster-randomized trial.

Recombinant shingles vaccination and the risk of cardiovascular events.

Oligodendrocyte dysfunction in human age-related cognitive decline.

Two exemplary cases of minimal and extensive dismemberment.

Individual-Level Interventions for Alcohol-Related Harm in Night-Time Entertainment Precincts: A Scoping Review.

Remodeling lipid and mitochondrial homeostasis: a novel mechanism by which polydatin attenuates renal tubular senescence in chronic kidney disease.

Risk perception and spatial mobility on the Camino de Santiago: travel patterns analysis and the choice of Jacobean routes.

Breaking the Chain: HIV-1 Transmission Clusters among People who Inject Drugs in North Carolina, 2010 to 2023.

Timely provisional surveillance of suicides using data from CDC's National Violent Death Reporting System: a cross-sectional analysis of data from 50 US states, the District of Columbia and Puerto Rico, January-June 2024.

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Protect the killer: CTLs need defenses against the tumor

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