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Staphylococcus aureus endocarditis in preterm neonates.

D Armstrong1, M R Battin, D Knight

  • 1Department of Neonatal Paediatrics, University of Auckland, National Women's Hospital, Green Lane Hospital, Auckland, New Zealand.

American Journal of Perinatology
|August 2, 2002
PubMed
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Staphylococcus aureus septicemia in extremely low birth weight infants can lead to endocarditis, even without murmurs. Prompt echocardiography and aggressive antibiotic treatment improve outcomes for this invasive infection.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pediatric Cardiology

Background:

  • Central venous catheter use in extremely low birth weight infants poses risks.
  • Staphylococcus aureus septicemia is a serious concern in neonates.

Observation:

  • Three extremely low birth weight infants developed Staphylococcus aureus septicemia after central venous catheter insertion.
  • Endocarditis was diagnosed via echocardiography, with large vegetations noted in all cases, despite only one infant presenting with a murmur.

Findings:

  • A 6-week course of intravenous flucloxacillin and netilmicin led to complete resolution of endocarditis in all infants.
  • No further intervention was required for the endocarditis itself.

Implications:

Related Experiment Videos

  • Echocardiography is crucial for detecting invasive Staphylococcus aureus infections, including endocarditis, in neonates, even without typical clinical signs like murmurs.
  • Aggressive antibiotic therapy can lead to favorable outcomes in neonatal endocarditis.
  • While endocarditis was treatable, other complications like chronic lung disease and volvulus can impact infant mortality.