[Is insertion/deletion polymorphism angiotensin-converting enzyme gene responsible for long-life?]

I/D polymorphism of ACE gene is the most frequent examined polymorphism and probably very strongly connected to pathology. The majority of studies describe negative influence of allele D on frequency and course of given diseases. The result of negative effect of this allele should be visible in people with long life expectancy. To answer the question: is I/D polymorphism ACE gene responsible for long-life, a comparison was made of the genotype map of a group of 101 long-life subjects with a group of 494 younger persons. The examination used polymerase chain reaction methods. The results were calculated using the programme Statistica 5.1 PL. One used the independent chi 2 test and Odds Ratio to compare the genotype map and localisation of alleles. After having made comparative examination no connection was made between I/D polymorphism ACE gene and long-life.