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Hypoglycaemia and lactic acidosis in a MALT non Hodgkin's lymphoma
Gabriele Di Comite1, Lorenzo Dagna, Piero M Piatti
1Department of Internal Medicine DIMER, IRCCS H. San Raffaele, Milan, Italy.
Abstract:
Hypoglycaemia associated with lactic acidosis is a rare complication of lymphomas; only four cases have been previously reported. Recent studies provide evidence of direct consumption of glucose by the tumour cells, leading to lactic acidosis. We report the case of a 64-year-old patient with a gastric diffuse large B cell non-Hodgkin's lymphoma transformed from an indolent mucosa associated lymphoid tissue (MALT) lymphoma, admitted to our department for acute renal failure due to a tumour lysis syndrome. After recovery from renal failure, she developed severe hypoglycaemia and lactic acidosis refractory to therapy. She died after the onset of shock and coma.
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