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A novel strategy for the synthesis of medium-sized lactams
Hans Bieräugel1, T Paul Jansen, Hans E Schoemaker
1Institute of Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, The Netherlands.
Organic Letters
|August 3, 2002
Abstract:
[reaction: see text] A novel method for the synthesis of medium-sized lactams based on an auxiliary-mediated combined tethered/templated strategy is presented. Cyclization by a tethered ring-closing metathesis reaction was followed by a templated transannular aminolysis reaction to give seven- to ten-membered lactams in good yields.