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A general method for the formation of aryl-sulfur bonds using copper(I) catalysts
Craig G Bates1, Rattan K Gujadhur, D Venkataraman
1Department of Chemistry, University of Massachusetts, Amherst 01003, USA.
Organic Letters
|August 3, 2002
Abstract:
[reaction: see text] We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 degrees C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.