Related Experiment Videos
Immunosuppression in renal transplantation: current status and application in developing countries
1Department of Medicine, University of Nairobi, P.O. Box 19676, Nairobi, Kenya.
African Journal of Health Sciences
|November 1, 1994
Summary
Renal transplantation success has surged due to immunosuppressive drugs like azathioprine and cyclosporine. This review details their dosing, administration, and side effects, considering global accessibility.
Area of Science:
- Nephrology
- Immunology
- Pharmacology
Background:
- End-stage renal failure (ESRF) treatment increasingly relies on renal transplantation.
- Significant advancements in patient numbers and survival rates over the last decade.
- Immunosuppressive pharmacotherapy is pivotal to transplant success.
Purpose of the Study:
- To comprehensively review current immunosuppressive medications used in renal transplantation.
- To detail the dosing, administration, and adverse effects of these vital drugs.
- To discuss the economic implications and accessibility of immunosuppressants in developing nations.
Main Methods:
- Literature review of immunosuppressive agents.
- Analysis of dosing, administration routes, and common adverse effects.
- Examination of drug costs and availability in diverse healthcare settings.
Main Results:
- Key immunosuppressants include azathioprine, corticosteroids, cyclosporine, FK 506, anti-thymocyte globulin (ATG)/anti-lymphocyte globulin (ALG), and OKT3.
- Established protocols exist for dosing and administration, but adverse effects require careful monitoring.
- High drug costs present a significant barrier to widespread use in developing countries.
Conclusions:
- Immunosuppressive drugs are essential for modern renal transplantation.
- Careful management of drug regimens is necessary to optimize outcomes and minimize toxicity.
- Addressing the cost and accessibility of these medications is crucial for global equity in transplantation.