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Related Experiment Videos

Increased intestinal ABCA1 expression contributes to the decrease in cholesterol absorption after plant stanol

Jogchum Plat1, Ronald P Mensink

  • 1Department of Human Biology, Maastricht University, Maastricht, Netherlands. J.Plat@HB.UNIMAAS.NL

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|August 3, 2002
PubMed
Summary

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Plant stanols lower cholesterol by reducing absorption and increasing efflux via ABCA1 transporter. This mechanism may involve LXR pathway regulation of intestinal lipid metabolism.

Area of Science:

  • Nutritional Science
  • Molecular Biology
  • Biochemistry

Background:

  • Plant stanols lower cholesterol by inhibiting intestinal absorption.
  • Previous research suggested intracellular actions of plant stanols within enterocytes.
  • The role of ATP binding cassette (ABC) transporters in cholesterol absorption was recently elucidated.

Purpose of the Study:

  • To investigate the hypocholesterolemic mechanism of plant stanols.
  • To explore the involvement of ABC transporters in plant stanol action.
  • To test the hypothesis that plant stanols enhance cholesterol efflux.

Main Methods:

  • Utilized caco-2 cells as a model for human intestinal lipoprotein metabolism.
  • Investigated the effect of sitostanol and cholesterol-sitostanol mixtures on ABCA1 expression.

Related Experiment Videos

  • Analyzed potential regulation of plant stanol action by SREBP-2 and LXR pathways.

    • Main Results:

    • Mixed micelles with sitostanol induced ABCA1 expression in caco-2 cells.
    • Findings suggest plant stanols promote ABCA1-mediated cholesterol efflux into the intestinal lumen.
    • Hypothesized that intracellular plant stanols are sensed by SREBP-2 and LXR.

    Conclusions:

    • Plant stanols may increase intestinal cholesterol efflux via ABCA1.
    • The LXR pathway might be a target for dietary regulation of intestinal lipid metabolism.
    • This mechanism explains the hypocholesterolemic effect of plant stanols beyond reduced absorption.