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Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis
R P Donn1, A Farhan, A Stevans
1Arthritis Research Campaign Epidemiology Unit (ARC/EU), Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Objective:
To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA).
Methods:
Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls.
Results:
None of the polymorphisms investigated showed any statistically significant associations with JIA.
Conclusions:
The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.