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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
(1SR,2RS,5RS,6SR,8RS)-7,7-Dimethyltricyclo[6.2.1.0(1,6)]undecane-2,5,6-triol: a supramolecular framework built from
Swastik Mondal1, Monika Mukherjee, Arnab Roy
1Department of Solid State Physics, Indian Association for the Cultivation of Science, Jadavpur, Calcutta 700 032, India.
Abstract:
In the title compound, C(13)H(22)O(3), the asymmetric unit has two independent molecules linked by a strong O-H...O hydrogen bond. The cyclohexane ring is trans fused to the cyclopentane ring bridged through an ethyl moiety. The hydroxyl groups act as donors as well as acceptors, resulting in an extensive two-dimensional hydrogen-bonded network in the (011) plane. Intermolecular O-H...O bonds between centrosymmetrically related molecules form a four-membered supramolecular assembly, leading to infinite chains parallel to the [011] direction, crosslinked in the [100] direction.
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