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Updated: May 5, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
Published on: May 26, 2011
ERM proteins and merlin: integrators at the cell cortex
Anthony Bretscher1, Kevin Edwards, Richard G Fehon
1Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. apb5@cornell.edu
Abstract:
A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function.
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