Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA methylation and breast carcinogenesis.

Martin Widschwendter1, Peter A Jones

  • 1USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, California, CA 90089-9181, USA. Martin.Widschwendter@uibk.ac.at

Oncogene
|August 3, 2002
PubMed
Summary

DNA methylation changes are key to breast cancer development, impacting hallmarks of cancer. This review explores how these epigenetic alterations can be targeted for early detection and prevention strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individualised progesterone receptor modulator prevention strategies for triple-negative breast cancer in BRCA1 pathogenic variant carriers.

NPJ breast cancer·2026
Same author

Bone marrow immunosuppressive states associate with survival after guadecitabine and atezolizumab therapy in HMA-R/R MDS.

Blood neoplasia·2026
Same author

Transforming endometrial cancer diagnosis: the case for molecular triage in abnormal uterine and post-menopausal bleeding.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Cost-Minimization Analysis of the Women's Cancer Risk Identification-Quantitative Polymerase Chain Reaction Test for Endometrial Cancer Epigenetic Biomarker Compared With Transvaginal Ultrasound for Triaging Abnormal Uterine Bleeding.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2026
Same author

Nucleosome spacing regulates linker methylation by DNMT3A2/3B3.

Molecular cell·2026
Same author

Roadblocks: Evaluating the impact of fines-related driver's license suspension on work-related outcomes for socioeconomically disadvantaged workers.

The Journal of applied psychology·2026

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Despite advances in understanding breast carcinogenesis, effective early detection and prevention strategies remain limited.
  • DNA methylation alterations, particularly gene promoter hypermethylation, are common in human cancers and lead to gene silencing.

Purpose of the Study:

  • To review the role of DNA methylation in acquiring cancer cell capabilities.
  • To explore the potential of DNA methylation changes for early detection and prevention of breast cancer.

Main Methods:

  • Literature review focusing on DNA methylation in breast carcinogenesis.
  • Analysis of how DNA methylation contributes to cancer hallmarks (e.g., limitless replication, immune evasion).

Main Results:

Related Experiment Videos

  • DNA methylation plays a crucial role in enabling cancer cells to acquire key capabilities, including sustained growth and metastasis.
  • Epigenetic modifications like DNA methylation are fundamental to cancer development.

Conclusions:

  • DNA methylation alterations are central to breast cancer progression.
  • Targeting DNA methylation could lead to novel strategies for early detection of premalignant lesions and breast cancer, and potentially for prevention.