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Published on: June 21, 2013
[Peptide-protein complexes of angiotensins in the mechanisms of thirst]
A V Kotov1, S M Tolpygo, E I Pevtsova
1Anokhin Research Institute of Normal Physiology of the Russian Acad. Med. Sci., Moscow 103009, 11 Mokhovaya St., Russia.
Abstract:
The comparative analysis of learned and natural drinking behavior under native angiotensin-I (A-I), angiotensin-II (A-II) and its protein-peptides complexes (PPC) administration in rats, was performed. Various effects of these substances on drinking behavior were observed. PPC of A-I became a dipsogenic agent as compared with the native one. Moreover, PPC of A-II facilitated selectively learned and not natural forms of drinking behavior. It's suggested that PPC of angiotensins play a specific role in endogenous mechanisms of thirst. An important function of this complexes due to their conformational properties and participation in realization of basic needs, is discussed.
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