[Mechanisms of bile secretion in mini-pigs (author's transl)]

The mechanisms of bile excretion are investigated in 27 experiments in 21 mini-pigs. The results confirm the known three fractions of bile flow for mini-pigs, too: a canalicular bile acid dependent, a canalicular bile acid independent and a ductular bile acid independent bile flow. These different fractions of bile flow may be stimulated either by taurocholate, by phenobarbital and ioglycamide or by secretin and pancreozymin. The total bile acid pool amounts 4,4 mMol. Measurements of its distribution over the gallbladder and the enterohepatic circulation after fasting for 18-24 hours emphasize the importance of the gallbladder resp. the fasting as factors that may be responsible for the secretion of lithogenic bile.