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Published on: March 9, 2018
[Exhalation diagnosis with C14 tagged compounds, methods and results]
Schweizerische Medizinische Wochenschrift
|June 7, 1975
Summary
The 14C exhalation test tracks metabolic changes from radiotherapy and other conditions. This method helps assess recovery times and aids in gastroenterology and thyroid function studies.
Area of Science:
- Biochemistry
- Nuclear Medicine
- Metabolic Research
Context:
- Radiotherapy for malignant diseases induces significant metabolic disturbances.
- Understanding long-term metabolic consequences, such as impaired glycocholate absorption post-pelvic radiotherapy, remains crucial.
- The 14C exhalation test offers a method to quantify these metabolic shifts.
Purpose:
- To present the methodology and findings of the 14C exhalation test for metabolic studies.
- To evaluate metabolic changes and recovery timelines in patients undergoing radiotherapy.
- To explore the utility of the 14C exhalation test in gastroenterology and endocrinology.
Summary:
- The 14C exhalation test was utilized with various 14C-labeled substrates (triglycerides, glycocholate, histidine, uridyl) to assess metabolic alterations in patients undergoing radiotherapy.
- Results indicate the test's capability to reveal the extent of metabolic changes and estimate the duration for returning to a normal metabolic state.
- Persistent disturbances in glycocholate absorption after pelvic radiotherapy were observed, warranting further investigation.
Impact:
- Provides a quantitative method for assessing metabolic disturbances and recovery post-radiotherapy.
- Expands applications to gastroenterology for studying bile salt absorption and to endocrinology for evaluating thyroid hormone effects on metabolic state.
- Paves the way for further radiobiological evaluations using metabolic testing.
